In vivo 19F MRS and 19F 2D-CSI investigation of a fluorine labeled 2-Nitroimidazole (TF-MISO). A potential functional reporter of hypoxia in solid tumors.
Procissi D, Claus F, Ling C, Koutcher J, Koziorowski J, Burgman P, Matei C, Thakur S
Memorial Sloan Kettering Cancer Center, California Institute of Technology
We report a 19F magnetic resoance spectroscopy (MRS) and 19F chemical shift imaging (CSI) in vivo investigation of a 2-Nitroimidazole agent labeled with three fluorine atoms (TF-MISO) . In vitro cellular uptake results have shown how this compound is hypoxia selective. Here we demonstrate how it is possible to use it (1) as a in vivo 19F MRS reporter of hypoxia in solid tumors, (2) how it is possible to functionally image the tumor distribution of the compound by 19F CSI and, using the same radio frequency setup, 3) obtain high resolution anatomical 1H reference images which provide context in terms of tissue hetereogeneity.