Abstract #1310

Vejby Sgaard L, Stavngaard T, Schreiber W, Schmiedeskamp J

Hyperpolarized 3He ADC is a sensitive probe of the micro-structure in the lung and may have the potential to detect early changes in emphysema and to monitor treatment response in patients. However, the ADC dependence on inspiration level has not been studied in much detail previously. In this work the ADC was measured for four different inspiration levels in three healthy subjects. The ADC values were found to increase with increasing respiratory level. Careful control of the inspiration status is nescessary in order to detect small changes in longitudinal studies and in the diagnosis of early emphysema.