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Abstract #1311

Nonlinear fitting method for high resolution mapping of Apparent Diffusion Coefficient (ADC) by hyperpolarized 3He

Yu J, Ishii M, Kadlecek S, MacDuffie Woodburn J, Emami K, Rajaei S, Hammond F, Vahdat V, Rizi R, Lipson D, Gefter W, Cheatham L, Clark T
University of Pennsylvania

Hyperpolarized 3He diffusion MRI imaging shows the promise of measuring the lung structure at the microscopic level non-invasively, characterized by the Apparent Diffusion Coefficient (ADC)[1]. The conventional linear fitting method is prone to noise perturbation when image resolution is high. We present here a nonlinear fitting technique for accurate high resolution ADC mapping.