Abstract #1311

Yu J, Ishii M, Kadlecek S, MacDuffie Woodburn J, Emami K, Rajaei S, Hammond F, Vahdat V, Rizi R, Lipson D, Gefter W, Cheatham L, Clark T

Hyperpolarized 3He diffusion MRI imaging shows the promise of measuring the lung structure at the microscopic level non-invasively, characterized by the Apparent Diffusion Coefficient (ADC)[1]. The conventional linear fitting method is prone to noise perturbation when image resolution is high. We present here a nonlinear fitting technique for accurate high resolution ADC mapping.