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Abstract #1454

In Vivo Measurement of Blood Flow After Traumatic Brain Injury in Rats Using Susceptibility Weighted Imaging

Shen Y, Kreipke C, Hu J, Haacke E, Petrov T
Wayne State University School of Medicine

Magnetic resonance imaging and, in particular, susceptibility weighted imaging (SWI) is proving to be a sensitive means to monitor changes in function after traumatic brain injury (TBI). In this study, we have focused on an in vivo rat model post TBI after a weight drop has induced brain damage. The rats are then scanned over a number of time points from several hours to several weeks. The blood phase analyses in SWI imaging suggests local and global reductions in blood flow in agreement with arterial spin labeling methods and previous results published in the field.