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Abstract #1469

Timecourse of early CBF changes after controlled cortical impact in mice.

Foley L, Hitchens T, Melick J, Kochanek P, Ho C
Carnegie Mellon University

Trauma can produce alterations of physiological processes such as cerebral autoregulation due to hypoperfusion, therefore it is important to study how targeting cerebral hemodynamics may improve neurological outcome. Approximately one hour after injury cerebral blood flow (CBF) was lowered over the entire ipsilateral hemisphere and it remained that way over the course of the experiment. Animals that had a craniotomy only, had lowered CBF in a pattern similar to the injured animals, but CBF recovered in all regions except the cortex under the contusion by experiment end.