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Abstract #1479

Acute Administration of Nicotine Reduced myo-Inositol and GABA levels in nucleus accumbens in rats

Liachenko S, Durham R, Badura L, Snyder P
Pfizer, Inc.

The potential reinforcing properties of compounds are an important consideration in the development of CNS-active drugs. Myo-inositol is a marker of glial-neuronal interactions, which are one mechanism of modulation of rewarding properties of addictive compounds. We found that acute administration of nicotine decreased the concentration of myo-inositol and GABA measured with MRS at 7 Tesla in nucleus accumbens in rats. Further investigation of addiction mechanisms and development of biomarkers for drug research is warranted.