Pre-processing Strategies to Improve Longitudinal MRI Repeatability
Xu X, Wong K, Young G, Wong S
Brigham and Women's Hospital
Image registration has been commonly used in MRI in putting different images together at the same spatial coordinates for normalization and comparison purposes. 2D acquisitions are known to produce inaccurate registration due to the highly anisotropic voxels. In mouse brain MRI, 2D techniques are frequently used to achieve high spatial resolution and to avoid physiological motion artifacts of in 3D sequence. In this paper we presented some strategies to characterize registration accuracy and how to accurately image the same location every time on the same mouse. It would be useful in monitoring disease progression as well as improving detection accuracy.