Abstract #1577
             Reproducibility of 1H-MR spectroscopic imaging in the centrum semi-ovale in patients with multiple sclerosis
             Hoogduin H,  De Keyser J,  van der Grond J,  Mostert J
             University Medical Center Groningen, University of Groningen
             The reproducibility of 1H-MR spectroscopic imaging at the centrum semi-ovale over a time span of 4 weeks was investigated in clinically stable MS patients. NAA/Cr ratios were reproducible with a coefficient of variation of 5.3 and 3.9% in gray and white matter, respectively. This indicates that 1H MR spectroscopic imaging can potentially be used as a surrogate marker in MS.