rCBV Estimates in Tumor vs. Normal Brain Depend on Acquisition and Analysis Methods
Paulson E, Prah D, Schmainda K
Medical College of Wisconsin
The goal of this study was to investigate how different acquisition and analysis methods influence rCBV estimate variations in tumor versus normal brain. Two methods were used to acquire dynamic T2*-weighted images and rCBV was determined by numerical integration over the entire concentration-time curve and by fitting a gamma-variate function to the first pass of the concentration-time curve. Gamma-variate and numerical integration derived rCBV values were found to be similar in normal brain, but this agreement diminished in regions of tumor. These results signify the dependence of rCBV estimates on acquisition and analysis methods.