Abstract #1611

Vestergaard-Poulsen P, Hansen B

The underlying cellular mechanisms responsible for the ADC change seen in stroke are still uncertain. In a brain tissue model including T2 relaxation and exchange effects model output from all combinations of a wide range of values of all model parameters were compared with experimental data obtained from grey matter in normal volunteers to ensure global solutions. The results support the hypothesis that T2 relaxation cannot be neglected in modelling water diffusion of brain tissue due to indications of slow exchange and T2 heterogeneity between compartments hence predicting a dependence of the ADC on the echo time