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Abstract #1619

The Intracellular Water Diffusion Coefficient of Cultured Microbead-adherent HeLa Cells is &[ge] 1 &[micro]m2/ms

Ackerman J, Neil J, Zhao L, Kroenke C
Washington University in St. Louis

A flow-related MR method was used to select the intracellular water signal from perfused microbead-adherent mammalian cells. By this means, the diffusion properties of intracellular water of HeLa cells were studied at various diffusion times. A statistical model of intracellular water diffusion fit the data well and was validated with optical microscopy. The intracellular water &[Prime]free&[Prime] diffusion coefficient is &[ge] 1 &[micro]m2/ms.