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Abstract #1691

In-vivo Micro-MRI of Trabecular Bone in the Ovariectomized Rhesus at 3T

McCracken P, Williams D, Cook J, Mathers P, Holahan M, Duong L, Kimmel D, Hargreaves R
Merck Research Laboratories

Osteoporosis is currently assessed using BMD measurements, which does not characterize the microarchitecture of trabecular bone, a better predictor of fracture risk. Trabecular bone -MRI was used to examine bone architecture (BVF, TrN, TrTh, TrSp) in sham operated and ovariectomized rhesus monkeys as a model for osteoporosis and compared to traditional BMD measurements. These -MRI studies on bone morphology in the OVX model suggest this technique may have value in assessing bone disease and in drug discovery and development. The data suggest -MRI can evaluate key parameters of bone structure extending our ability to assess bone pathology beyond BMD measurement.