Skeletal muscle degeneration and regeneration following femoral artery ligation in the mouse, as monitored using diffusion tensor imaging
Drost M, Strijkers G, Nicolay K, van Bochove G, Heemskerk A
The aim of this study was to evaluate quantitative diffusion MRI for monitoring tissue regeneration following femoral artery ligation in mice. The apparent diffusion coefficient (ADC) was increased and decreased after ligation at 3 and 10 days, respectively, whereas T2 was increased. Regional differences between the ADC and T2 response were observed which corresponded with histological findings of swollen cells and inflammation, respectively. Therefore, the data strongly suggest that the combination of DTI and T2 MRI enables the differentiation of the degenerative and regenerative phases in muscle regeneration.