Temperature dependence of T1 relaxation time of new long-circulating thermosensitive liposomes with encapsulated gadodiamide
Lindner L, Issels R, Peller M, Reinl H, Hossann M, Teichert N, Reiser M, Wang T
University Hospital Grosshadern, Ludwig-Maximilians-University
Recently, a novel formulation of long-circulating thermosensitive liposomes with encapsulated gadodiamide for MR thermometry has been developed. It showed the potential to both release the cytostatic drug and monitor the temperature during the tumor treatment using the combined chemotherapy and hyperthermia. In this work, T1 of these liposomes was measured, while heated from 30C up to 50C and subsequently cooled down. The results revealed that the gadodiamide/drug was released due to the phase transition at about 41C, consistent with the therapeutic temperature for the combined therapy. Moreover, the temperature during the treatment could be derived from the measured T1.