Comparison of Gd-Bz-TTDA, Gd-EOB-DTPA and Gd-BOPTA in Dynamic MR Imaging of the liver with Rat Models
Chen S, Hsu J, Shen F, Wang Y, Liu G, Jaw T
Kaohsiung Medical University
To evaluate the competitive potential of a new lipophilic paramagnetic complex, Gd-Bz-TTDA with the commercially available MR hepatobiliary contrast agents Gd-BOPTA and Gd-EOB-DTPA, dynamic MR imaging studies for normal and hepatocellular carcinoma (HCC) rats models were performed using a 1.5- T scanner. The results revealed that the enhancement of liver in normal rats injected with 0.1 mmol/kg Gd-Bz-TTDA was significantly more intense and persistent than those injected with the same dose of Gd-EOB-DTPA or Gd-BOPTA after 5 minutes. All agents showed similar enhancement pattern of the implanted HCCs. The liver-lesion contrast to noise ratios were higher in the rats injected with Gd-Bz-TTDA after 30 minutes. The results indicated that Gd-Bz-TTDA can be competitive to the commercially available hepatobiliary agents, Gd-EOB-DTPA or Gd-BOPTA by its more intense and prolonged liver enhancement, which providing better liver-lesion discrimination.