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Abstract #1855

Transcription MRI Contrast Probe Enables the Detection of Different Cerebral Messenger RNA Levels

Huang S, Rosen B, Liu P, Liu C, Dai G

Visualization of gene transcription in vivo is very important for genotyping, phenotyping, and accessing alterations in gene transcription during normal development or disease processes. Here we report an MR imaging probe that allows us to detect and visualize diferent mRNA transcript levels from two genes in live animals. This molecular imaging probe will enable us to study molecular processes at mRNA level in healthy and diseased animal models.