Diagnostic Accuracy of Contrast-enhanced MR Angiography with Various Doses of Gadobenate Dimeglumine&[micro]
Schneider G, Manfredi R, Thurner S, Grazioli L, Parker J, Pirovano G
Homburg University Hospital
A parallel-group blinded read was conducted to evaluate 4 doses of gadobenate dimeglumine for CE-MRA in terms of the accuracy (sensitivity and specificity) for detecting significant steno occlusive disease in renal, pelvic and carotid arteries. Eighty-four patients with suspected disease of the renal, pelvic or carotid arteries underwent CE-MRA (3D-SPGE sequences at 1.5 T) and DSA. CE-MRA was performed using dose of 0.025, 0.05, 0.1 or 0.2 mmol/kg (21, 25, 17 and 21 patients, respectively). Assessment of MRA and DSA images was performed on a segmental basis by 4 independent experienced radiologists. Overall accuracy was for CE-MRA was high, especially at the 0.1 mmol/kg dose level (95.2-97.3%, p<0.01 for 0.1 dose vs other doses).