A Magnetic Resonance Spectroscopy Technique for Evaluating Lung Preservation Strategies
Peltz M, Meyer D, Chao R, Jessen M, He T
University of Texas Southwestern Medical Center at Dallas
The optimal lung preservation conditions for lung transplantation remain controversial. We evaluated the effect of preservation temperature and percent alveolar oxygen on rat lung metabolism by carbon-13 decoupled proton magnetic resonance spectroscopy of lung extracts. Oxygen content and preservation temperature influenced pulmonary metabolism and energetics, particularly after long-term storage. This method offers promise as a rapid and inexpensive technique for testing multiple preservation conditions.