2D and 3D RINEPT (1H)-31P-MRSI in the human brain and its possible application to schizophrenia
Wokrina T, Ende G, Ulrich M
Central Institute of Mental Health
An altered metabolism of membrane phospholipids has been hypothesized in schizophrenia and various 31P MRS studies have been undertaken to explore possible changes in the phosphomonoesters (PME) and phosphodiesters (PDE) signals. Here a 2D slice selective and a 3D 31P MRSI sequence using RINEPT editing are compared with respect to time demand, spatial resolution and applicability to psychiatric patients. The PME and PDE resonances can be well resolved into phosphoethanolamine, phosphocholine, glycerophosphoethanolamine and glycerophosphocholine resonances. Both sequences have showed to be useful in clinical routine for the study of a possibly altered membrane phospholipid metabolism in schizophrenia even at the low field strength of 1.5 T.