High Energy Phosphate Abnormalities Normalize after Antipsychotic Treatment in Schizophrenia: A Longitudinal 31P MRS Study of Basal Ganglia.
Gangadhar B, Venkatasubramanian G, Keshavan M, Narayan J
National Institute of Mental Health & Neurosciences
It has been hypothesized that neuroleptics might induce decreased energy demanding processes. Earlier, we have reported increased high-energy phosphate metabolism, consistent with disturbed fronto-striatal activity in antipsychotic-nave schizophrenia. We followed up these patients for one year reassessed them using Magnetic Resonance Spectroscopy for the effect of antipsychotic treatment on the abnormalities of high-energy phosphate metabolism of basal ganglia. Patients had significantly lower mean PCr/ATP ratio than healthy controls at baseline but not during the follow-up. The observations support the hypothesis that neuroleptics might invoke reduced energy demanding processes.