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Abstract #2100

Texture Response of Deep Gray Matter in Patients with Multiple Sclerosis Treated with Minocycline

Zhang Y, Yong V, Zhu H, Mitchell J, Metz L
University of Calgary

Deep gray matter (GM) texture change in patients with multiple sclerosis (MS) after minocycline treatment was quantified using the recently developed polar Stockwell transform (PST) analysis on 3T T2-weighted MRI. The texture tended to change from coarseness to finesse 24 months on drug. Such changes were higher in active than in inactive patients. The texture improvement was the largest in the head of the caudate nucleus. This study suggests that the PST may be a new tool to monitor deep GM pathology. Future studies seek to verify these results and to correlate MR texture with clinical indicators of MS.