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Abstract #2136

Discordant Responses to Cocaine in CBF and CBV: Implications for phMRI CMRO2 assessment

Schmidt K, Luo F, Ferris C, Duong T
UMass

Two potential confounding effects of extending fMRI CMRO2 calculation to pharmacological studies were investigated by simultaneous direct measurements of CBF and CBV in the same experimental animal. While CBF showed a monophasic increase after cocaine infusion, CBV demonstrated a biphasic response with an initial decrease in CBV followed by prolonged CBV increase. A clear CBF-CBV discordant response to cocaine administration was found during the initial period. CBF-CBV recoupled during the steady state, however, with a significant lower value in cortical and subcortical regions. Those two effects confound phMRI CMRO2 method on evaluating cerebral oxygen metabolism following cocaine administration.