Mapping Neuropharmacological-Evoked BOLD Signals in Rat Brain under Isoflurane Anesthesia: A Feasibility Study
Robbins M, Zhu J, Guo X, Wang P
Wake Forest University School of Medicine, Wake Forest University School of Medicine
-chloralose has been used for anesthetic in most fMRI studies on rats, because it preserves neuronal-hemodynamic coupling and have the largest functional response comparing to other anesthetics. But the need of mechanical ventilation and difficulty to maintain animal in a stable physiological conditions over long duration when applying -chloralose to rats make isoflurane an interesting substitute. Using multishot SE-EPI on isoflurane anesthetized rats, reliable amphetamine evoked BOLD contrast change was detected in rat brain.