Characterization of Plaque Components in Gadofluorine M-Enhanced Rabbit Atherosclerosis: Toward Quantification of Plaque Progression with Biomechanics
Zheng J, Tang D, Misselwitz B, El Naqa I, Deasy J, Abendschein D
Washington University School of Medicine
The aim of this study is to evaluate the signal behaviors of multi-contrast atherosclerotic plaque images with Gadofluorine M enhancement in a double-injury rabbit plaque model. In addition, plaque progression was observed with two consecutive MRI scans. Morphology changes in different plaque components were addressed. For one animal, biomechanical stress and strain maps were obtained, in which shear stress and strain increased significantly, whereas the areas of foam cells increased and lumen remained unchanged.