Atherosclerotic plaque characterization using NMR spectroscopy
Rabbani S, da Silva E, Hanaoka M, Bloise A, Bonagamba T
So Paulo University, So Paulo University
Cardiovascular and cerebrovascular diseases, currently the first and third cause of death in developed countries, will soon be a major burden to public health worldwide and therefore there is a great effort to study vascular diseases using different techniques. The aim of the present study is to investigate the feasibility and the efficiency of MRS in detection of different stages of human atherosclerotic plaques. We show that the 13C and 1H High-Resolution spectra reflect the disease severity as the consequence of lipid alterations and consequently the NMR spectra changes.