Liver Function Test using SVD-based Deconvolutional Analysis in Gd-EOB-DTPA-Enhanced MRI
Nordell A, Nilsson H, Jonas E, Blomqvist L, Vargas R
Karolinska University Hospital
Calculating hepatic extraction applying deconvolutional analysis (DA), will remove the effect of contrast recirculation. Using DA, one thus estimates a hepatic extraction/time curve as if a single bolus contrast passage was used. DA was performed using singular value decomposition (SVD), which is a more robust method than Fourier based DA. In this pilot study we describe dynamic Gd-EOB-DTPA MRI as a segmental liver function test, where we compare traditional contrast enhancement parameters such as time to peak and relative peak value with the hepatic extraction fraction (HEF).