Abstract #2248

Stanwell P, Ramadan S, Mountford C, Bourne R, Katelaris P

Apparent diffusion coefficient (ADC) measured by MR in-vivo reflects physical properties of tissue that correlate with the microscopic architectural structure seen at histopathology. Measurements of ADC on 33 patients by diffusion-weighted EPI at 3T with a single element endorectal surface coil demonstrate more significant differences between benign peripheral zone tissue and adenocarcinoma than previously reported from 1.5T studies. Measurement of ADC of prostate tissue at 3T provides significant diagnostic information to improve the sensitivity and specificity of prostate cancer detection and staging by MR.