Could we accurately measure in vivo diffusion coefficients of brain metabolites using single-voxel MR spectroscopy?
Zhao T, Zhou L, Hu X
Emory University/Georgia Tech
In vivo diffusion coefficients of water and NAA were determined with localized spectroscopy measurements and were shown to depend on the voxel size. With voxel size less than 10 ml, the measured diffusion coefficients of water in phantom, water in vivo, and NAA in vivo were 2.04 10-3 mm2/s, 0.85 10-3 mm2/s and 0.17 10-3 mm2/s, respectively, in agreement with earlier reported values using similar voxel size. However, with voxel size as big as 24 ml, the measured in vivo diffusion coefficients of water and NAA were 1.5 ~ 3.0 times those of small voxels