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Abstract #2528

Automatic repositioning of CSI grids in 1H MRS: impact on reproducibility of metabolite concentration measurements

Turk K, Gonzalez G, Ratai E, Blezek D, Hancu I

Longitudinal 1H chemical shift imaging (CSI) exams to study the effects of disease or treatment are becoming increasingly common. One of the sources of variability in such exams arises from imperfect re-localization of the CSI grid in the follow-up exams. A novel approach, based on a priori image registration and acquisition of follow-up CSI grids with identical coverage and orientation as in the baseline exam, is presented here. Streamlined workflow, reduced variability of metabolite concentration measurements, and increased voxel overlaps are noted when this automatic repositioning procedure is compared to the visual CSI grid repositioning approach.