Direct Generation of 1H- and 13C-Hyperpolarized Molecules for MRI from Parahydrogen via Reversibly Functioning Catalysts
Bargon J, Rizi R
University of Bonn, University of Pennsylvania Medical Center
Parahydrogen-Induced Polarization (PHIP) yields strong nuclear spin polarization of protons and heteronuclei including 13C. Because of the relatively long T1 relaxation times of quarternary carbons especially, 13C-hyperpolarized molecules appear intrinsically more attractive as contrast reagents for MRI than their 1H-hyperpolarized counterparts. We have demonstrated a technique for reversibly hydrogenating potential contrast agents to generate a hyperpolarized version of a target molecule without synthesizing an unsaturated precursor as was previously required. This development should speed the creation and testing of hyperpolarized agents for bloodflow and molecular imaging.