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Abstract #2655

Evidence for elevated brain iron concentration in patients with

Ramani A, Hu C, Lu H, Ferris S, Szulc K, Jensen J, Helpern J
New York University School of Medicine

The purpose of this study was to detect differences in brain iron concentration in patients with Alzheimer disease, subjects with mild cognitive impairment and age-matched controls using magnetic field correlation (MFC) imaging, a novel quantitative MRI method for estimating brain iron. The MFC is a sensitive measure of the regional distribution of iron in the brain, and can be measured using an asymmetric spin echo sequence. We have previously provided feasibility of this method in-vivo. In this abstract, we have measured regional brain MFC values using parametric MFC maps and histogram analysis.