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Abstract #2662

Describing Magnetization Transfer Parameters in White Matter Using a Four-Pool Model

Bjarnason T, MacKay A
University of Calgary

In the literature, the NMR behaviour of white matter has been modeled using either two or four proton pools. In this study, the magnetization transfer (MT) two-pool model parameters were derived from the results of a recent four-pool model investigation of white matter in bovine brain. The two-pool MT parameters derived from the four-pool model were in good agreement with previously published two-pool model results. Since the two-pool model ignores the known existence of two water reservoirs in white matter, we believe that future work on modeling MT results should involve at least four pools.