A new approach using the distribution of transit times (DTT) to determine improved absolute CBF values in patients with ischemic stroke
Frayne R, Salluzzi M, Smith M
Seaman Family MR Research Centre, Foothills Medical Centre, Radiology, University of Calgary
A positive patient outcome after ischemic stroke depends on an accurate diagnosis. Absolute cerebral blood flow (CBF) values are often obtained using a scaling factor determined via MR-PET cross-calibration. We propose a new approach using the distribution of transit times (DTT) to estimate CBF values. Simulation studies indicate that is it more appropriate to use a single cross-calibration factor with DTT-based CBF estimates than with CBF values from conventional deconvolution algorithms. The DTT-based approaches lead, therefore, to better (less systematically biased) characterization of the perfusion level in brain tissue.