Quantitative Cerebral Vascular Response Maps: Determination with Pulsed Arterial Spin Labelling
Noeth U, Kotajima F, Deichmann R, Turner R, Corfield D
GSF Forschungszentrum fuer Umwelt und Gesundheit, Institute of Neurology, UCL
Hypoxia is a pathological factor associated with respiratory diseases (e.g. sleep apnea). As the brain is particularly vulnerable to effects of hypoxia, the aim of this study was to acquire quantitative perfusion maps of grey matter under isocapnic and hypoxic conditions from which cerebral vascular response (CVR) maps can be calculated. These CVR maps show the local variability of the cerebral vascular response to hypoxia and might help to identify areas which are most prone to damage under hypoxic insults.