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Abstract #2702

Quantitative Analyses of Dentate Nuclei and Cerebellar Peduncles Based on DTI in Langerhans Cell Histiocytosis

Zhang W, Zhang J, Huang H, Arceci R, van Zijl P, Mori S
Johns Hopkins University, School of Medicine, Kennedy Krieger Institute

Langerhans cell histiocytosis (LCH) is a rare disorder characterized by the clonal proliferation of immature Langerhans cells. Imaging of this disorder is inadequate in predicting progression of neurologic deterioration. We applied DTI to 4 patients with LCH and compared the white matter anatomy with 6 age-matched controls. Substantial volume loss was found in the dentate nuclei (DN) and the superior cerebellar peduncle (SCP) in all patients. The DN was difficult to define on conventional MRI, but clearly delineated on average DWI and color-coded orientation maps. The DN volume measurement by DTI may provide a useful tool for patients with LCH.