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Abstract #2719

Fractional anisotropy as a tool for characterization of white matter fiber tract integrity in the aging rhesus monkey brain

Coimbra A, Holahan M, Tymofyeyev Y, Hargreaves R, Cook J, Williams D
Merck Research Laboratories

We explored the possibility of using DTI as a longitudinal tool for probing fiber integrity in the rhesus monkey by evaluating reproducibility of fractional anisotropy (FA) measurement in the corpus callosum (CC) in a group of four young adult monkeys. Second, as part of a continuing effort to evaluate the potential of quantitative MRI to characterize aging in the primate brain, we made FA measurements in the CC of 47 monkeys aged 3-30 years.