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Abstract #2771

Cerebral Blood Volume: Measurement and Change

Turner R, Thomas D
University College London

SYNOPSISTechniques for measurement, by MRI and optical means, of cerebral blood volume (CBV) are compared and contrasted. At least three different physical quantities are commonly described by this term. The Monro-Kellie argument relating to CBV changes is reviewed, and a novel mechanism for the observed CBV changes during functional activation is proposed, with experimental predictions.