Hemodynamic Response in Human Central Olfactory System
Yang Q, Smith M, Ansel L, Grunfeld R, Sun X, Meadowcroft M, Zimmermann E, Eslinger P, Wang J
Penn State College of Medicine
The hemodynamic response function to odors was studied on eight normal human subjects with a single odor single strength stimulation fMRI paradigm. The hemodynamic response was modeled with different length of stimulations using SPM2. The hemodynamic response function modeled with shortened length of stimulation yielded stronger activation map at the same confidence level. This is quantitatively demonstrated by the activation volume in the primary olfactory cortex and the entire brain. These analyses indicate a rapid decay of hemodynamic signal responding to the odor after onset of stimulation.