Change of ADC value of breast cancer in patients undergoing neoadjuvant chemotherapy: preliminary study
Cai Y, An N, Jin G
PLA General Hospital
Many studies have shown that tumor water diffusion is associated with tumor cellularity. To our knowledge whether diffusion MRI can reflect response of breast cancer to neoadjuvant chemotherapy in the tumor cellular level by ADC (apparent diffusion coefficient) value has not been reported. Fifteen women (total of 17 tumors) with biopsy-confirmed breast cancer underwent bilateral breast MRI-DWI examination (GE EXCITE HD1.5T) prior to neoadjuvant chemotherapy (AT regimen) and after the first cycle therapy. Our results revealed ADC values of all tumors, except for 2, increased to different extent after neoadjuvant chemotherapy (P=0.001), although the size of most tumors shrunk only slightly after 1 cycle therapy. DWI can reflect response of breast cancer to neoadjuvant chemotherapy in the tumor cellular level by ADC value.