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Abstract #2881

Do diffusion changes occur prior to size changes in breast tumours undergoing neoadjuvant chemotherapy?

Lowry M, Turnbull L, Gibbs P, Pickles M
University of Hull

The purpose of this work was to determine if treatment induced tumour ADC changes occur prior to tumour size changes in a cohort of breast cancer patients undergoing neoadjuvant chemotherapy. The results of 12 patients revealed that significant changes in ADC values occurred after the 1st cycle (p=0.001) while changes in tumour size were not significant at this time-point (p=0.834) and only became apparent after the 2nd cycle of treatment (p=0.043). It is believed that the altered ADC values were as a result of increased water mobility following treatment induced cell damage.