Contrast-Enhanced MRI for Assessing the Response of Invasive Breast Cancer to Neoadjuvant Chemotherapy
Stolpen A, Park J, Karwal M, Garg M
Univ of Iowa
Neoadjuvant chemotherapy is used to decrease the size of locally advanced breast cancers prior to definitive surgery. This study evaluates the performance of serial contrast-enhanced MRI for assessing the response of twenty invasive breast cancers to neoadjuvant chemotherapy. MRI demonstrated a range of tumor behaviors, from disease progression, to partial response, to lesion fragmentation, to complete response. The findings at MRI predict the amount of residual cancer at mastectomy or lumpectomy, especially when MRI shows complete or near-complete complete tumor response.