Fast Exchange Regime Analysis of the Response to Treatment in Human Breast Cancer
Yankeelov T, Lepage M, Chakravarthy A, Niermann K, Herman C, McManus K, Kelley M, Mayer I, Meszoely I, Gore J
Vanderbilt University, Vanderbilt University
Models have been developed for analysis of dynamic contrast enhanced MRI (DCE-MRI) data that include the effects of transcytolemmal water exchange. It has been hypothesized that these models are more sensitive to tumor physiology. Here we present the first example of a DCE-MRI analysis of the response to treatment in human breast cancer which incorporates the effects of transcytolemmal water exchange.