DCEMRI detects effects of tumors on adjacent normal tissue that reflect tumor grade
Karczmar G, Zamora M, Fan X, Medved M, River J
University of Chicago
We studied contrast uptake and washout behavior in muscles near tumors to distinguish normal muscle from muscle near tumor, and to separate the metastatic from non-metastatic tumors. The low molecular contrast agent Gd-DTPA and higher molecular contrast agent P792 were used to acquire dynamic contrast enhanced MRI at 1.5T for rodent prostate cancer AT2.1 and AT3.1 tumors. The results demonstrated that the muscles near tumors were significantly different from the normal muscles and in addition metastatic and non-metastatic tumors have different effects on nearby muscle.