Abstract #2929

Rosen M, Flaherty K, Schwartz B, Heitjan D, O'Dwyer P

We demonstrate the effects of incorporating a measured arterial input function (AIF) in DCE-MRI quantification, using the results of a recently completed human trial of DCE-MRI to monitor early response of renal cell carcinoma to Sorafenib. Use of a measured, rather than assumed, AIF leads to dramatic alterations in the resulting tumor Ktrans values before therapy. Change in tumor Ktrans following treatment is significantly associated with clinical outcome (time to tumor progression) only when the measured AIFs are utilized.