Optimal quantification of DCE-MRI data using reference tissue normalisation
Walker-Samuel S, Collins D, Leach M, Knowles B, d'Arcy J, Brown G, Smith N
Institute of Cancer Research
It has been shown that spoiled gradient echo sequences can be designed such that changes in signal intensity are directly proportional to Gd-DTPA concentration in DCE-MRI measurements. This can be usefully exploited in reference tissue-based quantification methodologies. However, the choice of dynamic parameter used in such analysis (signal difference, relative enhancement or enhancement factor) significantly affects the uncertainty in the resultant quantitative parameters. This study aimed to compare the relative uncertainty in each dynamic parameter in order to evaluate which is most appropriate to use in this type of analysis.