Short Echo Spectroscopic Imaging combined with Lactate Editing in a single scan
Melkus G, Moerchel P, Kotas M, Jakob P, Flentje M, Behr V
University of Wrzburg
In this work, we have shown that a spectroscopic imaging method combined with a lactate editing filter can improve the metabolic information of lipid-rich tissues (e.g. necrotic tumors). After conventional chemical shift imaging, a multiple quantum coherence filter selectively prepares lactate and the signal is detected in a second acquisition window. With this sequence, it is possible to separate lactate from lipids in a single shot without losing the information from the complete 1H spectrum. The method was tested and confirmed using a phantom containing several different metabolites as well as a post-mortem mouse brain.