Quantified 19F MR spectroscopy reveals heterogeneous capecitabine metabolism in human liver
Heerschap A, Punt C, van Laarhoven H, Klomp D
Radboud University Nijmegen Medical Center
The aim of this study was to develop a method for quantified localized detection of fluorinated compounds in human liver. For this purpose sensitivity-optimized localized 19F MRS methods at 3 Tesla were used to detect MR signals from capacitabine, 5DFUR, 5DFCR and FBAL after oral intake of capacitabine. As the rf coil is made tuneable to 19F and 1H, the same localization method is applied to obtain 1H MR signals of water as for the 19F metabolites. Absolute concentrations are obtained of capecitabine and its metabolites in vivo which revealed a substantial spatial heterogeneity of these metabolites in human liver.