Effects of Aging on Hippocampal Subfields and Whole Brain Gray and White Matter Volumes Measured at 4 Tesla
Mueller S, Weiner M, Schuff N, Stables L, Du A, Cashdollar N, Truran D
VAMC San Francisco
Aging can be associated with memory changes. However, the results of volumetric studies regarding an age-related loss of hippocampal volume are controversial. We measured hippocampal subfields in 53 healthy and cognitively normal controls (age range 18-85 years) on a high resolution T2 weighted sequence acquired on a 4T magnet. CA1 and entorhinal cortex (ERC) volumes but not other subfields were negatively correlated to aging. The volume loss in CA1 and ERC seemed to accelerate after the fifth decade of life. This was in contrast to volume loss in GM, which seemed to start early in life and progressed continuously.