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Abstract #3129

Cerebral Atrophy in End-Stage Renal Disease

Prohovnik I, Lee H, Post J, Sandu O, Sano M, Langhoff E
Mount Sinai School of Medicine, Bronx VAMC

Generalized cerebral atrophy has been found in patients with End-Stage Renal Disease by visual examination, but it has never been quantified or rigorously localized. We studied 10 patients and six controls, using the MMS and MPRAGE MRI scans analyzed by SPM99. We confirmed previous reports of sulcal dilatation and ventricular enlargement, found novel sites of focal atrophy in brain stem and caudate nucleus, and report quantitative relations of atrophy with age and cognitive deficits.