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Abstract #3145

Evidence for Detection of Ascorbic Acid in the Human Brain at 3T

Huell M, Kaufmann R, Buechert M, Hennig J, v. Elverfeldt D
University Hospital Freiburg

Quantification of vitaminC (Asc) is not trivial due to strong overlap with the spectra of other metabolites. This study aims to evaluate the potential detection with standard MRS in the human brain at 3T. Spectra of 37 healthy volunteers and the time dependency after an inter venous application were examined. LCModel was able to detect Asc and revealed a strong correlation to other metabolite concentrations. Furthermore a significant rise in Asc was observed in the time dependent data. Therefore this data provide strong evidence that ascorbic acid can be detected in the human brain at 3T via LCModel.